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KMID : 1098420150230010001
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Korean Journal of Medicinal Crop Science
2015 Volume.23 No. 1 p.1 ~ p.7
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Osteoprotective Effect of Extract from Cirsium japonicum var. ussuriense in Ovariectomized Rats
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Kim Young-Ock
Kim Jin-Seong
Lee Sang-Won
Jo Ick-Hyun
Na Sae-Won
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Abstract
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This study was carried out to investigate the effects of the Cirsium japonicum var. ussuriense (C. japonicum) extract on serum level of hormones from induced osteoporosis by ovariectomized rats. Two month-old rats were ovariectomized(OVX), remained untreated for 8 weeks, and were subsequently administered C. japonicum (200 ㎎/㎏) every day for 8 weeks. We examined the effects of treated C. japonicum on ovariectomy-related changes in Insulin-like Growth Factors
(IGF), Insulin-like Growth Factor binding protein-3 (IGBF-3), Estrogen, Calcium, and Phosporus. After 8 weeks, the serum
levels of IGF-I, -II, and IGFBP-3 were higher presented as compared to the other two groups (P < 0.05), in the C. japonicum extract treatment on OVX rats. There were differences between OVX and C. japonicum extract treated OVX rats in serum levels of Ca2+, but Ca2+ levels for the normal group was higher than for the other two groups. The C. japonicum extract increased both serum IGFs and IGFBP-3 levels on induced osteoporotic rat by ovariectomized. Thus, these results revealed that the C. japonicum extract is a possible role for improvement of osteoporosis induced-ovariectomized rats and has a great potential as an alternative tool for the treatment of osteoporosis.
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KEYWORD
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Cirsium japonicum, Osteoporosis, Ovariectomy, Serum
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